Endocrine Abstracts

Background: Stiff Person Syndrome (SPS) is an extremely rare neurological disorder, with an expected prevalence of less than 1 per million. The first described case of SPS in the literature was reported in 1959 by Moersch and Woltman. SPS is featured by progressive muscle stiffness, rigidity, and spasm involving the axial muscles, which may result in severely impaired ambulation. SPS seems to have an autoimmune basis although its exact pathogenic mechanism is still cloudy. Mos...

Background: Radioactive iodine 131I (RAI) treatment is an effective definitive treatment of hyperthyroidism, used as a first line or second line treatment.Aims and objectives1. To evaluate the response of RAI therapy in Graves’ disease.2. To determine any factors predicting treatment failure.Study design: Retrospective study: Materials and methods: Clinical ...

Introduction: Autoimmune polyendocrine syndrome 1 (APS1) is an uncommon, serious autosomal recessive disorder, due to AIRE gene mutations which result in impaired central tolerance. India has a complex genetic structure and also communities with high prevalence of consanguinity, which may result in varied clinical manifestations and genetic mutations.Aims: To study clinical features, interferon-α antibodies (IFNA), AIRE mutations, ...